Background:
Despite their many benefits to consumers, pharmaceutical DTC marketing sites, have the potential to misinform. This could have potentially far-reaching negative consequences on the health of consumers, compelling stringent oversight to assess the authenticity of the websites' claims. We examined pharmaceutical DTC websites to compare their claims of efficacy and side effect/ limitations against their references. This study is a direct, structured, observational study of pharmaceutical websites. The information of 4 randomly selected pharmaceutical DTC websites and their 5 drugs, were compared for the accuracy concerning efficacy, side effects and limitations with cited reference material. Analyses were scored as: Yes, No and Unsatisfactory.

Results:
A total of 45 claims of efficacy to 32 claims of drug side effects limitations were supported from corresponding referenced studies. The websites provided referenced support of 45 of the 65 claims of efficacy. Side effects and limitations were poorly represented with 32 of the 85 referenced claims being found in the corresponding websites in comparison to supporting articles.

Conclusions:
Majority of pharmaceutical websites provide a greater number and proportion of references regarding claims of efficacy as compared to side effects and limitations.